Nuclear Factor-Kappa B in Gliomas as a Predictive Factor for Tumor Recurrence – A Clinicopathological Study

BACKGROUND: Glioma is the most common primary malignant brain tumor. Nuclear factor κB (NF-κB) has emerged as a regulator of phenotype in glioma, and particular glioblastoma multiforme, with clear relation to tumor size, recurrence, invasiveness. AIM: The aim study was analysis NF-κB expression gliomas different histologic types grades its correlation various clinicopathologic indicators. METHODS: One hundred ten paraffin blocks glioma cases classified according WHO classification into 14 (12.7%) Grade I pilocytic astrocytoma, 27 (24.5%) II gliomas, 26 (23.6%) III 43 (39.1%) IV glioblastoma. correlations between immunostainings clinicopathological parameters were analyzed statistically. RESULTS: Positive immunostaining for encountered (64/110) 58.2% gliomas. Statistical revealed significant association positive high histological grade (p < 0.001), recurrence tumors = large size (≥5 cm) subtypes (glioblastoma represented 51.6% cases, while astrocytoma 1.6% cases) 0.001) age patient (≥40) 0.039). CONCLUSIONS: A strong direct observed. behaves negative independent prognostic risk recurrence. Hence, inhibition may be new therapeutic strategy prevent particularly high-grade type.